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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Kurarinone, TNF-related apoptosis inducing ligand
Phytochemical Name Kurarinone (PubChem CID: 11982640 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 133
Ref_1
Pair Name Kurarinone, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2B72.Z] Gastric cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Expression MCL1 hsa4170
Down-regulation Expression CFLAR hsa8837
Down-regulation Expression STAT3 hsa6774
Up-regulation Cleavage PARP1 hsa142
Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression CCNA2 hsa890
Down-regulation Expression CCNB1 hsa891
In Vitro Model SGC-7901 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0520
Result Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells
03. Reference
No. Title Href
1 Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. Cell Biochem Biophys. 2015 May;72(1):241-9. doi: 10.1007/s12013-014-0444-0. Click
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